INCa-funded position in the Team “Vecteurs: Synthèse, Applications & Toxicologie” from the Laboratoire de Conception et Application de Molécules Bioactives (CAMB, UMR 7199 CNRS-Unistra)
The VSAT team is looking to hire a post-doctoral fellow for an exciting project aiming at developing fluorescent carbon nanoparticles as drug carriers for combined therapeutic strategy targeting prostate cancer cells metabolism.
ABOUT THE POSITION AND PROJECT
This postdoctoral position is funded for 2 years (starting date: Feb. 2023) by the Institut National du Cancer (INCa). Cancer is a complex and heterogeneous disease involving multiple signaling pathways that enable tumor cells to evade cell death, thus making treatment highly challenging. In this context, combined therapies are increasingly used in clinical practice. This project is focused on prostate cancer and we will develop carbon dots (CDs) as innovative nano- particles for combined chemotherapy and gene therapy. For that purpose, CDs will be designed to deliver both an inhibitor of oxidative phosphorylation and a short interfering RNA targeting a key enzyme involved in the glycolytic flux control, specifically to prostate cells, track them using bioimaging techniques, and test their efficacy in inducing apoptosis in tumor cell lines. The post-doctoral fellow will be in charge of the synthesis, physical, and photophysical characterization of the CDs before their in vitro and in vivo evaluations. These biological evaluations will be performed by two Inserm groups located in Strasbourg and Nice.
ABOUT THE TEAM AND ENVIRONMENT
More at http://camb.cnrs.fr/vsat
ABOUT THE PROFILE
We are seeking for an organic chemist with knowledge in nanoparticle synthesis and characterization. Experience in cell culture and gene delivery would be appreciated. Post-doctoral applicants willing to apply for a permanent researcher position are strongly encouraged to apply.
ABOUT THE APPLICATION
The candidate should send a cover letter, CV, and recommendation letters to Dr. Luc Lebeau (email@example.com).
CAMB – VSAT, Faculté de Pharmacie, 74 route du Rhin – F67401 Illkirch http://camb.cnrs.fr/vsat